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doi: 10.3389/fphys.2022.840065 Received 20 December 2021 Accepted 31 January 2022 Published 24 February 2022 Volume 13 - 2022 Edited by John D

R.Diaz-RuizA.FrhbeckG.MalagonM

Unlike mice and rats, guinea pigs naturally resemble the human lipoprotein profile and develop human-like NASH histopathology, dyslipidemia, and hepatic oxidative stress when fed a Western diet [131,132,133]

Importantly, idiopathic DCM is a diagnosis of exclusion, so both acquired and congenital cardiac disease in addition to systemic non-cardiac disease must all be excluded