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The authors (Nicholas D Buchanan, Jacob A Grimmer, Vineeta Tanwar, Neill Schwieterman, Peter J Mohler and Loren E Wold) note that there is a significant knowledge void to fill, as the the long-term effects of vaping on the cardiovascular system were essentially unstudied

The WHO and CDC define heavy smoking as 20 or more cigarettes per day which equals exactly one pack per day

Smoking is from plants

That's why it's essential to understand how any substance might interfere with these processes