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Cellular compartmentalization, glutathione transport, and its relevance in some pathologies

In fibroblasts, cellular ROS-induced mTORC2 activity concomitantly promotes autophagy [86, 87], while in keratinocytes, mTORC2 is a critical link between mtROS and autophagy

Knock-down of states within the cell can be directly incorporated into the dynamic modeling framework by adjusting the protein production rates of Nrf2, Keap1 and p62 for the corresponding knock-downs

High levels of ROS have also been shown to alter the expression patterns of several housekeeping genes, such as FOX3A, NF kappa B, and AP-2