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increased levels of proinflammatory cytokines, which correlate with increased production of reactive oxygen species and oxidative stress

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184,185 Upregulated USP20 expression in oxaliplatin-resistant HCC cells is associated with poor prognosis, while genetic knockdown or pharmacological inhibition of USP20 can trigger ferroptosis and increase the sensitivity of HCC cells to oxaliplatin both in vitro and in vivo

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