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We did not detect changes in bone marrow cellularity in young, middle-aged, or aged WT and Mda5 -/- animals (Supplementary Fig

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F2, Factor 2

Br J Sports Med

The apoptosis inhibitor X-linked inhibitor of apoptosis protein (Xiap) binds to Smac to inhibit the initiation phase of apoptosis, and to Caspase-3 to inhibit the execution phase of apoptosis [20]