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doi: 10.1016/S0891-5849(97)00140-8

DMR-2242375)

demonstrated that exposure to polylactic acid (PLA) MPs and their oligomers induces mitochondrial calcium overload in midbrain neurons by upregulating MICU3, a key mitochondrial Ca 2+ uptake regulator, thereby initiating mitochondria-dependent apoptotic pathways 38

Additionally, these fatty acids help rebalance vital neurotransmitters, such as serotonin and dopamine, essential for the functioning of the trigeminovascular nociceptive pathway, and can inhibit TNF- expression, potentially reducing cerebral vasodilation implicated in migraine episodes