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These enzymes are responsible for the synthesis of prostaglandins, which are the primary mediators of pain, fever, and inflammation

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Additionally, for both brain and intestinal tissues, primers were used for tumor necrosis factor alpha (TNF-), interleukins 1 beta (IL-1), 6 (IL-6), and 17 (IL-17), inducible nitric oxide synthase (iNOS), heme oxygenase-1 (HO-1), and superoxide dismutase 1 (SOD1) and 2 (SOD2)