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Data availability The expression datasets analyzed for this study can be downloaded from the TCGA database ( The correlation between drug sensitivity and mRNA expression was analyzed using the Gene Set Cancer Analysis (GSCA) database ( The relationships between sorafenib and four ferroptosis-related genes in RCC were analyzed using the Genomics of Drug Sensitivity in Cancer (GDSC) database ( All data generated or analyzed during this study are included in this article

In vitro studies provide further mechanistic insight, showing that lithium enhances mitochondrial function, supports oxidative balance, and prevents apoptosis through mechanisms involving cytochrome c regulation, Bcl-2 modulation, and preservation of complex I activity

doi: 10.1016/j.mehy.2009.12.020 75 Panner SelvamMKAgarwalAHenkelRFinelliRRobertKAIovineCet al

The sequestration of oxidized glutathione and detoxification of H 2 O 2 in vacuoles during oxidative stress may be involved in the control of cytosolic redox potential and redox state of target molecules and subsequently in the regulation of cell division, differentiation, and defense

Minet A, Manceau A, Valada-Mennuni A, BraultFavrou M, Churlaud C, Fort J, Nguyen TM, Spitz J, Bustamante P, LacoueLabarthe T (2020) Mercury in the tissues of five cephalopods species: first data on the nervous system