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This is the closest human dataset informing IGF-1 LR3 risk

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

A critical underlying mechanism involves oxidative stress (OS), an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, which disrupts endothelial function, reduces nitric oxide (NO) bioavailability, and contributes to vascular dysfunction

These results suggest that combining immunotherapy with dietary restriction may lead to profound synergistic effects

If any of these are present, a shortage of B12 should urgently be considered as a cause