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IGF-1 DES lacks the first three amino acids at the N-terminus of IGF-1, it has enhanced potency (about 10-fold in vivo) relative to IGF-1

Fernndez-Espejo E, Rodrguez de Fonseca F, Gavito AL, Crdoba-Fernndez A, Chacn J, Martn de Pablos (2022) Myeloperoxidase and advanced oxidation protein products in the cerebrospinal fluid in women and men with parkinsons disease

Furthermore, in vitro cellular and molecular methods demonstrated that Nle-AngIV stimulated dendritic spine numbers, increased spine size, and enhanced miniature excitatory postsynaptic currents in hippocampal neurons

Summary of different animal models are listed in Table 2

In the first month, the changes are almost entirely internal