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C.Masterson Tavares Pereira FerreiraD.Almeida EsmerinoE.et al (2022)

Our work showed that acrolein exposure of cultured hepatocytes led to a sustained activation of ERK1/2, JNK, and p38, which was associated with ER and mitochondrial stress and apoptosis

Aestivation in nature: physiological strategies and evolutionary adaptations in hypometabolic states

Lets just say it againyou should NOT give a loading dose with warfarin Most patients being treated with warfarin need to be bridged with heparin/enoxaparin anyway (with a notable exception in afib patients, who dont usually require bridging), and loading with warfarin does not remove this need

Glutathione acts as the "exhaust fan" for the mitochondria, cleaning up that oxidative stress so the power plants can keep running efficiently