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Description

Kurdekar A D, Chunduri L A, Chelli S M et al

Recent studies on bacterial urease C (UreC) have shown that urease inhibitors can disrupt the growth environment of Mtb and inhibit its reproduction by preventing UreC from interacting with RuvB-like protein 2 (RUVBL2) and impeding the formation of RUVBL1-RUVBL2-RAD51 DNA repair complex, thereby suppressing host DNA repair mechanisms