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Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain

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These studies not only identified an easily detectable prognostic biomarker but also highlighted the crucial role of sphingolipids in PCa progression

The inflammasome can also be activated through a non-canonical pathway through sensing of internalized LPS, leading to the activation of caspase 4, also referred to as caspase 11, for the release of IL-1, IFN, and NF-B (106108)

In contrast, -amylase acts as an endonuclease, and the down-regulation of its activity reduces the random breakage of starch molecules and prevents the sudden accumulation of excess reducing sugars from impacting cellular osmotic homeostasis [84, 85]