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Ulusoy A, Phillips RJ, Helwig M, Klinkenberg M, Powley TL, Di Monte DA

Spermatozoa are particularly susceptible to the action of high concentrations of ROS due to the presence of a large amount of polyunsaturated fatty acids in their plasma membrane as well as a low concentration of enzymes in the cytoplasm that can neutralize ROS [11]

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Hansra and colleagues have mapped the increased iron deposition in the hippocampus, parietal lobe and motor areas of Alzheimers disease tissues, where the deposition sites coincide with neurofibrillary tangles and amyloid plaques

Furthermore, both cell development and the maintenance of different functions require the engagement of GPX4, as its genetic knockout or inactive form of expression leads to embryonic death lethality and subfertility in male mice (Cardoso et al., 2017