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Drug sensitivity analysis further demonstrated that patients in the high and low gene score groups exhibited significant differences in sensitivity to various anticancer agents ( Figure 10G )

Polyamine metabolism in cancer Overview of polyamine metabolism in cancer Nucleotide metabolism, represented by DNA metabolism, and epigenetic regulation both depend on one-carbon metabolism to maintain genome integrity, and one-carbon metabolism provides sufficient amount of methyl groups for nucleotide, amino acid, and lipid synthesis, of which methionine cycle-dependent polyamine synthesis is important for cancer cell growth and development [260,261,262]

3A), upon glucose exposure, ascertaining the cells capacity to perform glycolysis

Skeletal abnormalities, learning disabilities, larger-than-average-head-size, and tumours on optic nerves that cause poor vision can also be the symptoms of NF1

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