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4 Haem-iron is an important mediator of NTHi pathogenesis and persistence The success of NTHi as a pathogen is reliant on its ability to perform interactions with the host, many of which are regulated directly or indirectly by the bioavailability of haem or other iron-containing moieties (Harrison et al., 2013)

Kaspars Tars, [email protected] These authors have contributed equally to this work