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Over the last few decades, they appear to have declined for most of the Great Lakes (see Figure 1)

has shown in patients with RA enrichment of peripheral blood mononuclear cells (PBMCs) in cells expressing the gut-homing markers LPAM-1 and CCR9 and the percentage of LPAM-1 + CCR9 + PBMCs was positively correlated with disease activity [3]