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Results from a randomised double-blind placebo controlled study showed the initiation of early caffeine did not reduce the age of first successful extubation, rates of BPD, or the duration of need for supplemental oxygen when compared with the placebo group and this trial was halted due to a non-significant trend towards an increased mortality rate in the caffeine group (97)

Symptomatic improvement when vitamin E was added to the treatment regimen was occasionally reported, but data for hepatic WD are mainly anecdotal because no rigorous studies have been conducted

doi: 10.3390/ijms19030907 66 MoXShenXMoXYuFTanWDengZet al

Discussion Dadachamame, from Tsuruoka in Yamagata Prefecture, Japan, showed higher levels of FAA and sucrose than the prevalent soybean cultivar from the early seed formation stage (R5) through the edamame stage (R6) (Fig

Acknowledgements This work was supported by the US National Institute of General Medical Sciences (grant F32 GM082028 to D.M.R