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Matrix 9 , 3439, (1989)

Circulation 133 , 24592502 (2016)

Salivary trimethylamine N-oxide: a novel non-invasive marker for periodontal inflammation

doi: 10.1002/jcp.26015

Under normoxic conditions, HIF-1 is rapidly hydroxylated by prolyl hydroxylase domain (PHD) enzymes, which promotes its recognition by the von HippelLindau (VHL) E3 ubiquitin ligase complex, leading to ubiquitination and subsequent proteasomal degradation (Zhang et al., 2025)