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[54] found that human CD8 + T cells, either from lung tissue of COPD patients or exposed to cigarette smoke condensate, expressed more TLR4 and TLR9 proteins as compared with controls, while CSE also induced the activation of circulating CD8+ T cell with an increase in cytokine expression

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L4 remains in the tissues for approximately two months

Bundgaard, T., Wildt, J., Frydenberg, M., Elbrond, O

Association Between Clinical Manifestations and Prognosis in Patients with COVID-19