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Conclusion: These findings confirm that the addition of NMR-analyzed myoinositol and valine improved the correlation of GFR NMR with mGFR concerning bias and precision in liver disease, and accurately differentiates liver function scoring

Recommendation 5: Liver biopsy should be considered in HCC patients receiving molecular targeted therapy and/or ICIs under the following conditions: (1) Liver injury cannot be clearly attributed to anti-tumor therapy, necessitating further investigation

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The Ninth International Conference on Learning Representations (ICLR, 2021)

9,13 Other mechanisms of hepatotoxicity include the formation of toxic free radicals, such as peroxynitrite, from the reaction of superoxide and nitric oxide, subsequently forming nitrotyrosine adducts inside the mitochondria