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ICs were shown to inhibit the adaptive immune responses in an NLRP3-dependent model during priming of immune responses in vivo, 67 suppression of both inflammasome activation and the generation of IL-1 alpha and IL-1 beta from antigen-presenting cells were observed

These contemporary observations complete a circle of research which started with the initial investigations into the mechanisms of learning and memory implicating pka and pkc (Ghirardi et al., 1992

however, these findings remain predictive and require validation through in vitro and in vivo studies

(4) Mitochondrial protection: activation of mitophagy and related pathways is proposed to remove damaged mitochondria, thereby limiting mitochondrial ROS production that fuels ferroptosis

(Hassanien, Manal, et al