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and (3) increased Nrf2 levels in lung tissues to prevent ubiquitination or deubiquitination of Nrf2, thereby facilitating its nuclear translocation and inhibiting ferroptosis

Nutrigenomic interactions involving genes such as APOE, MTHFR, SIRT1, and Nrf2 have been implicated in modulating oxidative stress responses, lipid metabolism, and neuroinflammatory pathways