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17 PI3K/AKT signaling contributes to cellular survival by inhibiting pro-apoptotic factors such as BAD and by promoting cell cycle progression via the phosphorylation of mTOR

Histologic sampling in selected work suggested increased keratinocyte activity and dermal density patterns compatible with the matrix findings above

Proliferative concern: As a potent growth signal, IGF-1 activity raises theoretical concern about promoting growth of pre-existing abnormal cells a genuine reason for caution, not a casual muscle aid

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