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While a dominant-negative effect might have been anticipated, heterozygous mice are normal, while homozygous mice have severe defects of cornea, mildly impaired growth, skin fragility, and mild skin extensibility a substantially different phenotype from classical EDS due to COL5A1 haploinsufficiency

Baseline characteristics of subjects The baseline characteristics of the 30 female subjects are shown in Table 2

Physiological and pathophysiological functions of intestinal mast cells

87 However, aspirin disrupts the normal degradation of -catenin by interfering with the destruction complex, including Axin, APC, GSK3, and PP2A

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