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Importantly, no simple, one-to-one relationship between transcription factors and organ emergence within the endoderm has been reported

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Fatal and non-fatal adverse events of glucocorticoid therapy for Graves orbitopathy: a questionnaire survey among members of the European Thyroid Association

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Instead, clinical success often depends on a balance between disease-relevant expression, pathway context, and the ability to achieve functional selectivity through dosing, delivery, or molecular mechanism