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These data suggest that the hypoxic response might affect the Ras/ERK signaling pathways downstream to neurofibromin loss and its genetic inactivation installs a hypoxic-like response that may provide cells with an equipped and prompt response to any possible drop in oxygen availability

Creatinine is a byproduct of digestion

5ac, Additional file 1: Fig

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In type 1 sequences the Cys residues are exclusively arranged in Cys-Xaa-Cys motifs (Xaa represents another amino acid) in both the N- and C-terminus, while type 2 have Cys-Cys, Cys-Xaa-Xaa-Cys, and Cys-Xaa-Cys sequences in the N-terminal domain and Cys-Xaa-Cys in the C-terminal domain