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Georgopoulos, Sheffield Hallam University, United Kingdom Updates Copyright 2025 Tang, Zhang, Chen, Zhou and Lin

Oral supplements: can work for mild deficiency and maintenance in people who absorb B12 normally, but tend to take longer and are less reliable when absorption is impaired

Limited half-life and stability Liposomes for their limited half-life and susceptibility to degradation and fusion present significant challenges in drug delivery

2006 Richards F, Cooper MR, Pearce LA, Cowan RJ, Spurr CL: Familial spinocerebellar degeneration, hemolytic anemia, and glutathione deficiency

The CGI-Improvement scale (CGI-I) was used to evaluate the degree of improvement in the patients symptoms relative to the baseline, and the CGI-Efficacy Index (CGI-EI) assessed the clinical efficacy of bumetanide by considering both the treatment effect and associated side effects