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Specifically, it has been reported that stimulation of tumor -adrenergic receptors increases the production of several factors that promote metastasis, including vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMP-2 and MMP-9), and pro-inflammatory cytokines such as IL-6 and IL-8 (Wrobel et al., 2020

This leads to excess mucous production, leading to persistent coughing and breathing difficulties

With regard to age, the burden of most substance use subtypes increased with age

3 (London: H.G