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In humans, NMN doses as high as 1,200mg/day and daily NR doses up to 2,000mg have been illustrated as safe for use over a six-week period.4 31 So, a daily dose of either NMN or NR or a combination of the two up to 1,200mg should be perfectly safe for most people

It works by increasing serotonin signaling in the brain

10.1128/MCB.01868-08 49 Muoz-EspnD.CaameroM.MaraverA.Gmez-LpezG.ContrerasJ.Murillo-CuestaS.et al (2013)

Gonzalez-Palacios J

Luo C, Xu W, Tang X, Liu X, Cheng Y, Wu Y, Xie Z, Wu X, He X, Wang Q, Xiao Y, Qiu X, Tang Z, Shao G, Tu X (2022) Canonical wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation