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Cocaine abuse can produce long-lasting changes in the users brain including: Less sensitivity to natural reinforcers in the brain Negative moods Unhappiness when not taking the drug Anxiety Muscle spasms Risk of overdose Panic attacks Paranoia Psychosis Hallucinations and delusions Consistent nosebleeds Problems swallowing Hoarseness Irritation of nose lining Damage to the lungs (if smoked) Reduced blood flow in the GI track Digestive issues and ulcers Increased risk of stroke Inflammation of the heart muscle Aortic ruptures Heart attacks Bleeding in the brain Bulging in the walls of cerebral blood vessels Links to Parkinsons disease and other movement disorders Lasting effects on attention, impluse inhibition, memory, decision-making abilities, and motor skills What Are the Signs and Symptoms of Cocaine Withdrawal