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Antiinflammation effects and mechanisms study of geniposide on rats with collagen-induced arthritis

doi: 10.1016/j.pbb.2013.09.002

Ultraviolet A (UVA) and hydrogen peroxide (H 2 O 2 ) contribute to ROS generation, inducing oxidative stress in skin cells

Hirano A, Nakano I, Kurland LT, Mulder DW, Holley PW, Saccomanno G

Conversely, the randomized Phase III clinical trial NCT03268954 demonstrated that high-risk MDS patients treated with 5-Aza (75 mg/m 2 on days 15, 8/9 in 28-days cycles) + pevonedistat (20 mg/m 2 intravenously on days 15 in 28-day cycles) experienced significantly higher event-free survival (EFS) and OS compared to those receiving 5-Aza monotherapy (median EFS: 19.2 months vs 15.6 months