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4 Relationship between astrocytes and neuronal energy metabolism 4.1 General metabolic synergy between astrocytes and neurons Astrocytes not only sustain their own physiological activities but also provide crucial energy support to neurons, regulating synapse formation and information transmission

These characteristics, as previously discussed, make Exos a viable strategy to overcome the limitations of traditional central nervous system therapies

Lancet 361 , 16931699 (2003)

They include the PARG [poly-ADP ribosylation (PAR) glycosylase] inhibitor PDD00017273 19 , the PERK inhibitor GSK2606414 20 , and the HSP90 inhibitor luminespib 21 (Fig