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101 (70% of CVD) had current stroke/TIA

246 For example, SMAD2 ubiquitination by Itch/AIP4 promotes its phosphorylation by TRI, facilitating signal transduction

Treatments might include injections or high-dose oral supplements to restore B12 levels

-Tocopherol (30 mg/kg, i.p.) has shown beneficial effects in experimental renal ischemia, including reduction in tubular damage scores and cast formation, decreased blood urea nitrogen (BUN) and creatinine elevations, protection against oxidative DNA damage in renal tubular cells, and preservation of glomerular filtration capacity [53]