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Some evidence suggests that significant suppression of one pituitary function can sometimes have minor, downstream effects on others

Functional HIF-1 corresponding elements were found in the promoter sequence of the human BNP gene, proving that HIF-1 can induce the activation of the BNP promoter, the transcription of BNP mRNA, and the synthesis and secretion of BNP under hypoxic conditions [90]

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The pathogenesis of DN involves complex interactions among metabolic dysregulation, oxidative stress, inflammatory responses, and fibrotic signaling pathways (Figure 1)