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This is because it is water-soluble, so most ingested B12 is actually flushed out in the urine

5,10-Methylene tetrahydrofolate (THF) is required for the synthesis of nucleic acids and is reduced to 5-methyl THF by methylene THF reductase, a flavin-dependent enzyme that uses NADPH as a cofactor

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Lancet Respir Med 5(3):162164 Chun SH, Lee HA, Lee KB, Kim SH, Park KY, Lee KW (2016) Effects of glycated Whey protein concentrate on Pro-inflammatory cytokine expression and phagocytic activity in RAW264.7 macrophages

In general, alcohol-containing beverages that are darker in color (e.g., bourbon, red wine) typically have higher congener levels than those lighter in color (e.g., vodka, white wine) and are linked to triggering more pronounced hangover symptoms with more severe headaches (43, 44)