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Studies in growth hormone-deficient mice show that while other growth hormone secretagogues increased body fat through growth hormone-independent mechanisms that included increased feeding, ipamorelin's effects on body composition are primarily mediated through its growth hormone-releasing properties

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This evaluation reviews current health status, lab work, medications, and the patients specific goals to determine which combination makes clinical sense

The binding-induced conformational changes may facilitate the activation of G-proteins, which are signaling proteins hypothesized to be found on the intracellular side of the GHRH receptor