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The examination of prior studies resulted in different findings for the same treatment received due to potential confounding variables or biases not considered or not statistically controlled for, as well as considerations of statistical power and analysis, in conjunction with missing data that can affect the outcomes of clinical trials [116] (Fig

doi:10.2337/db14-0153

Sci Rep 2017;7:42516

Furthermore, gene expression analysis showed that ATF4 was induced at the transcriptional level by 24 h after serine and glycine deprivation regardless of the presence of the PHGDH inhibitor (Fig