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The initial step, the deamination of phenylalanine to trans-cinnamic acid, is catalyzed by phenylalanine ammonia lyase (PAL) [176]

In vitro barrier models using Caco-2 cells (gut epithelium) or brain endothelial cells could be employed to test the hypothesis that microbiota metabolites, such as butyrateeither administered directly or derived from patient-derived fecal microbiota culturescan strengthen epithelial and endothelial barrier function and reduce oxidative stress [40]

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Supports brain health: Acts as a neuroprotective agent and enhances brain energy production

The mutation in the uricase gene that occurred during food scarcity and global cooling resulted in a survival advantage at that time 16