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Among the three UPR sensors, namely inositol-requiring enzyme 1 (IRE1), protein kinase RNA-like ER kinase (PERK) and activating transcription factor 6 (ATF6), IRE1 and PERK have been more extensively implicated in the regulation of proinsulin folding

doi: 10.1038/s41422-025-01107-6 15 ZhangYQianCChuCYangXZWuYCaiLet al

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2017) for protocol-specific concentrations

The concentrations of serum amylase, lipase, total cholesterol and triglycerides were quantified utilizing a commercially available kit with an automatic biochemical analyzer (Roche, Germany), adhering closely to the provided manufacturers guidelines