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One possible source for an enzyme to catalyze the next step in a pathway evolving in the forward direction is the enzyme that catalyzed the last step, as this enzyme has a binding site that accommodates the product of the last reaction, and that product is the substrate for the next reaction

The most severe forms are caused by recessive mutations in ABCC8 and KCNJ11 coding for the subunits SUR1 and Kir6.2 of the ATP-sensitive K+ (K-ATP) channel on the pancreatic -cell membrane

2), metabolite analysis (Fig

10.1186/1743-0003-2-20 7 AnandhanA.TamilselvamK.VijayrajaD.AshokkumarN.RajasankarS.ManivasagamT

GSTM1 gene polymorphism and the risk of colorectal cancer in a Saudi Arabian population