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Pyruvate kinase isozyme M2 (PKM2) is one of the enzymes which are activated by the IGF-1/AKT axis [54, 55] (Fig

The elevated oxalate levels increase inflammation and fibrosis.[ref] Related article : Fatty liver disease NLRP3 inflammasome activation: The NLRP3 inflammasome is activated by increased ROS and calcium oxalate crystals