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It suggests that there is preferential activation of the c-MET receptors along the tumour invasive front compared with the tumour core

For example, p300/CBP promotes high mobility group box 1 lactylation while simultaneously inhibiting SIRT1 deacetylase activity via the Hippo/YAP pathway, thereby activating acetylation and ultimately exacerbating sepsis progression (75)

however, existing medications have limited efficacy and potential side effects, and evidence for non-pharmacological therapies remains limited

One of the main obstacles in developing efficient cancer vaccines with tumor-associated antigens is their limited ability to overcome immune tolerance

Having elucidated the ferroptosis-immune-metabolism axis as a key self-sustaining mechanism in COPD pathogenesis, these insights provide a foundation for novel therapeutic interventions