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To investigate whether albumin could be engineered to evade L585 cleavage and the resulting reduction in FcRn binding, we constructed a panel of 18 full-length 585-engineered human albumin variants, in which the C-terminal leucine residue was substituted with each of the other naturally occurring amino acids, except for cysteine (Fig

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Recombinant cells expressing both receptors produce more endosomal cAMP when GIPR-Ab/GLP- 1 binds to both receptors simultaneously and internalizes them quickly

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