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The immune response to autoantigens may exist many years before disease onset and lay outside the joints

doi: 10.1016/j.celrep.2017.07.054 15 HeZZhangS

In normal physiological conditions, various cellular activities generate reactive oxygen species (ROS), and the presence of counteractive antioxidant molecules serve as electron donors to neutralize and inhibit the accumulation of ROS, ensuring the integrity of the genome and other cellular protein structures