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The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism

A systematic review and meta-analysis of four adult and three pediatric studies showed that 6-TG nucleotide levels were higher in patients achieving biochemical remission, with no difference in 6-MMP levels or the 6-MMP/6-TGN ratio [90]

A randomized, double-blind, cross-over protocol was conducted, entailing the administration of NAC (2g/day) for 60 days and then placebo for another 60 days (or vice versa)

Measuring serum biomarkers such as B 12 or MMA is neither helpful nor indicated in assessing or monitoring clinical improvement.38 Base the injection frequency on symptoms, and not on biomarker assessment

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