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This membrane-targeting effect is particularly advantageous in anaerobic environments where antibiotic penetration is limited ( In addition to membrane disruption, polyphenols can interfere with microbial enzyme systems and protein synthesis ( Polyphenols also exhibit potent anti-biofilm activity, which is of particular importance in the context of periodontal disease ( A unique mechanism by which polyphenols exert antibacterial effects is through the inhibition of quorum sensing (QS)the cell-to-cell communication system that regulates virulence gene expression, biofilm maturation, and resistance traits in bacteria ( A

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