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However, recent clinical studies have highlighted the capacity of UA to significantly improve muscle endurance and exercise performance in older adults (6)

This method comprises administering to the subject an effective amount of a compound selected from the group consisting of Suitable and preferred subjects are as disclosed herein

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r in each case 1 Independently is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, halogen, -OR A1 -N(R A1 ) 2 -SR A1 (ii) a Wherein R is A1 Independently at each occurrence is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, oxygen protecting group (when attached to an oxygen atom), sulfur protecting group (when attached to a sulfur atom), nitrogen protecting group (when attached to a nitrogen atom), or both R A1 The groups join to form an optionally substituted heterocyclic ring or an optionally substituted heteroaryl ring