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B 715 (1998) 328

During a previous stint working with an industrial yeast manufacturer Bridge became interested in working with GGC, but discovered the difficulty of manufacturing the ingredient meant there were only tiny, expensive quantities available to use in his studies

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Vascular endothelial cells, smooth muscle cells and extracellular matrix gradually change, resulting in reduced endothelial function, a thickened intima, vascular sclerosis, increased arterial pressure, reduced number of capillaries and decreased permeability, which further cause tissue ischemia and hypoxia, oxidative stress damage and necrosis (7, 8)