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Recent studies have shown that combining GPX4 inhibitors with immune checkpoint blockade (anti-PD-1) exhibits superior effectiveness in inhibiting breast tumor growth compared to monotherapy (Yang et al., 2023b)

Panov A, Orynbayeva Z, Vavilin V, Lyakhovich V (2014) Fatty acids in energy metabolism of the central nervous system

The phosphorylated form of TBK1 (pTBK1) then rapidly phosphorylates the remaining pool of TBK1 molecules, culminating in the formation of fully-activated kinase dimers and amplifying the immune response through a cascade of signaling events [8, 9]